From North Suffolk / Smithfield 
Take Route 17 toward Norfolk

Continue on Route 17 until it turns into Route 164

Take 164 to 58E - Midtown Tunnel / Norfolk

Proceed through Midtown Tunnel

Once out of Midtown Tunnel follow signs to Medical Center / NS Railway

Follow signs to Medical Center to Gresham Dr.

Cross over Hampton Blvd. to Gresham Dr.
From Hampton / Newport News / Williamsburg (via Monitor-Merrimac Bridge Tunnel)

Take 64E to Exit 264: Route 664 South - Downtown Newport News / Portsmouth / Suffolk / Nags Head / Chesapeake

Proceed through Monitor-Merrimac Bridge Tunnel

Take exit 9N to Portsmouth / James River Bridge

Take LEFT exit to 164 East: Portsmouth

Take 164 to 58E- Midtown Tunnel / Norfolk

Proceed through Midtown Tunnel

Once out of Midtown Tunnel follow signs to Medical Center / NS Railway

Follow signs to Medical Center to Gresham Dr.

Cross over Hampton Blvd. to Gresham Dr.
From Hampton / Newport News / Williamsburg (via Hampton Roads Bridge Tunnel)

Take I-64 East through the Hampton Roads Bridge Tunnel

From I-64 East, take Exit 284-A (onto I-264 West heading toward Norfolk)

Continue onto I-264 West to Waterside Drive

Continue onto Waterside Drive until it become Boush St.

At the intersection of Boush and Brambleton Ave., turn LEFT

Continue on Brambleton Ave., cross over Colley Ave.

Bear RIGHT on Gresham Dr. into hospital campus
From the Outer Banks

Take Route 168 toward Norfolk, which becomes the Chesapeake Expressway, to I-464- Norfolk, Exit on Waterside Dr.

Continue on Waterside Dr. until it becomes Boush St.

At the intersection of Boush and Brambleton Ave., turn LEFT

Continue on Brambleton Ave., cross over Colley Ave.

Bear RIGHT on Gresham Dr. into hospital campus
From Emporia
Take Rt. 58 toward Norfolk, to I-264 heading to downtown Portsmouth / Norfolk

Follow I-264 signs to Portsmouth; go through Downtown Tunnel to Norfolk and exit on Waterside Dr.

Continue on Waterside Dr. until it becomes Boush St.

At the intersection of Boush and Brambleton Ave., turn LEFT.

Continue on Brambleton Ave., cross over Colley Ave.

Bear RIGHT on Gresham Dr. into hospital campus
From Elizabeth City

Take Route 17 toward Norfolk to I-464 North into downtown Norfolk

Take I-464 North into Norfolk and exit on Waterside Dr.

Take Waterside Drive, which becomes Boush St.

At the intersection of Boush and Brambleton Ave., turn LEFT

Continue on Brambleton Ave., cross over Colley Ave.

Bear RIGHT on Gresham Dr. into hospital campus
From the Eastern Shore

Take Route 13 South through the Chesapeake Bay Bridge Tunnel

Across the bridge, stay straight, road becomes Northampton Blvd.

Continue on Northampton Blvd. to I-64 East

Continue on I-64 East; take Exit 284-A (onto I-264 W to Norfolk)

Continue on I-264 West to Waterside Dr.

Continue on Waterside Dr. until it becomes Boush St.

At the intersection of Boush and Brambleton, turn LEFT

Continue on Brambleton Ave., cross over Colley Ave.

Bear RIGHT on Gresham Dr. into hospital campus
Best Departure Routes from Campus
To Midtown Tunnel
Take Gresham Dr. back out to Brambleton Ave. near Medical Tower.

Take right on Brambleton Ave.

Proceed to Midtown Tunnel.
To Waterside Dr. to 264 
Take Gresham Dr. to Fairfax Ave.

Take right onto Colley Ave.

Take left at Brambleton Ave.

Take right at Boush St.

Boush St. turns into Waterside Dr.