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Heart Failure Research 

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Sentara Cardiovascular Research Institute (SCRI) was established in 2005 by Sentara and its cardiac physicians to advance the understanding and treatment of cardiovascular disease. SCRI conducts numerous studies in conjunction with our Advanced Heart Failure specialists and these related studies are listed below:

Heart Failure Studies Conducted by the
Sentara Cardiovascular Research Institute (As of September 2009)

Title: The HeartMate II LVAS Pivotal Study Protocol, Destination Therapy
    PI: Michael McGrath
    Status: Open to enrollment

Title: The HeartMate II LVAS Pivotal Study Protocol, Bridge to Cardiac Transplantation
    PI: Michael McGrath
    Status: In follow up only

Title: Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF)
    PI: John Herre
    Status: Open to enrollment 

 Title: RESPONSE HF - Response of Cardiac Resynchronization Therapy Optimization With V-V Timing in Heart Failure Patients.
    PI: Allen Ciuffo
    Status: In follow up only

Title: A Study of Telemonitoring to Improve Heart Failure Outcomes
    PI: Jaime Murillo
    Status: Follow up only 

 Title: FREEDOM - A Frequent Optimization Study Using the QuickOpt Method
    PI: John Herre
    Status: In follow up only

Title: Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic HF (REDUCE hf)
    PI: Jaime Murillo
    Status: In follow up only

Title: Trial of Aldosterone Antagonist Therapy in Adults With Preserved Ejection Fraction Congestive Heart Failure (TOPCAT)
    PI: John Herre
    Status: Open to enrollment

Title: An evaluation of global and regional volumes as an independent predictor of response to cardiac resynchronization therapy.
    PI: Jaime Murillo/EVMS resident project
    Status: Open to enrollment

Title: REVERSE: Resynchronization reverses remodeling in systolic left ventricular dysfunction
    PI: John Herre
    Status: In follow up only 

 Title: DEFEAT PE: Detect Fluid Early from Intra-thoracic Impedance Monitoring.
    PI: John Herre
    Status: Enrolling

Title: SMART AV: Smart Delay determined AV Optimization: A comparison to other AV Delay Methods used in Cardiac
    Resynchronization.
    PI: Robert Bernstein
    Status: Enrolling

Title: A Feasibility Study to Determine the Effects of Synchronized Phrenic Nerve Stimulation in Patients with Periodic Breathing
    PI: John M. Herre,
    Status: Enrolling

Title: Identification of the Pericardiophrenic Vein During cardiac Resynchronization Therapy Procedures to Prevent Extracardiac
    Stimulation
    PI: John Herre
    Status: Enrolling 

 Title: MADIT-RIT, Multicenter Automatic Defibrillator Implantation Trial: Reduce Inappropriate Therapy
    PI: Robert Bernstein, MD
    Status: Enrolling


Heart Transplant Studies 

Title: A randomized, open label study to compare the safety and efficacy of conversion from a calcineurin inhibitor to sirolimus
    versus continued use of a calcineurin inhibitor in cardiac transplant recipients with mild to moderate renal insufficiency.
    PI: John Herre
    Status: Pre-approval


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