Clinical trials are generally considered to be biomedical or health-related research studies in people following a pre-defined protocol. Participants in clinical trials often gain access to new research treatments before they are widely available while contributing to medical research.
Patients benefit from these studies because they offer the standard chemotherapy or radiation, plus the opportunity to receive cutting-edge drugs or other therapies.
Administration of clinical trials requires an intensive degree of management, coordination and monitoring by the physicians and staff. Despite the increased amount of time and effort required, the physicians and nurses at Sentara Martha Jefferson willingly embrace clinical trials and strongly believe in the value and potential long-term benefits of participation to current patients and to the overall future of cancer care.
Current Clinical Trials at Sentara Martha Jefferson Hospital
Breast Cancer Trials
A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
Phase II placebo-controlled trial of lisinopril and Coreg CR to reduce cardiotoxicity in patients with breast cancer receiving (neo)adjuvant chemotherapy with trastuzumab (Herceptin)
ECOG – 1Z11
A Cohort Study to Evaluate Genetic Predictors for Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)
SWOG – 1202
A Randomized Placebo-Controlled Phase III Study of Duloxetine for Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptoms in Women with Early Stage Breast Cancer
Colon Cancer Trial
A Phase III Trial of 6 Versus 12 Treatments of Adjuvant Folfox Plus Celecoxib or Placebo For Patients With Resected Stage III Colon Cancer
Prostate Cancer Trial
A Phase III Trial Of Short Term Androgen Deprivation With Pelvic Lymph Node Or Prostate Bed Only Radiotherapy (SPPORT) In Prostate Cancer Patients with a Rising PSA After Radical Prostatectomy
The National Oncologic Pet Registry (NOPR) – F-18 Flouride Pet Scan
The Impact of Exercise on Fatigue in Newly Diagnosed Breast Cancer Patients While Receiving Radiation Therapy - Pilot Study (Newly diagnosed breast cancer patients)
ECOG = Eastern Cooperative Oncology Group
SABP = National Surgical Adjuvant Breast and Bowel Project
RTOG = Radiation Therapy Oncology Group
SCUSF = SunCoast CCOP Research Base at the University of South Florida
SWOG = Southwest Oncology Group