Clinical Trials

Clinical trials are generally considered to be biomedical or health-related research studies in people following a pre-defined protocol. Participants in clinical trials often gain access to new research treatments before they are widely available while contributing to medical research.

Patients benefit from these studies because they offer the standard chemotherapy or radiation, plus the opportunity to receive cutting-edge drugs or other therapies.

Administration of clinical trials requires an intensive degree of management, coordination and monitoring by the physicians and staff. Despite the increased amount of time and effort required, the physicians and nurses at Sentara Martha Jefferson willingly embrace clinical trials and strongly believe in the value and potential long-term benefits of participation to current patients and to the overall future of cancer care.

Current Clinical Trials at Sentara Martha Jefferson Hospital

  • Breast Cancer Trials

    ECOG 1Z11

    A Cohort Study to Evaluate Genetic Predictors for Aromatase Inhibitor Musculoskeletal Symptoms (AIMSS)

    NRG BR003

    A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer


    A randomized phase III trial comparing axillary lymph node dissection to axillary radiation in breast cancer patients (cT1-3 N1) who have positive sentinel lymph node disease after neoadjuvant chemotherapy


    Non-Invasive Confirmatory Detection of Breast Cancer

  • Colon Cancer Trial


    A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision

  • Lung Trials


    A Study to Evaluate a Panel of Blood Biomarkers for Use in Patients Undergoing Evaluation for Lung Cancer


    Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial

    (ALCHEMIST) A screening trial for A081105 and E4512


    Randomized Double Blind Placebo Controlled Study of Erlotinib or Placebo in Patients with Completely Resected Epidermal Growth Factor Receptor (EGFR) Mutant Non-small Cell Lung Cancer (NSCLC)


    A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Placebo for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein


    Adjuvant Nivolumab in Resected Lung Cancers (ANVIL) - A randomized Phase III Study of Nivolumab after Surgical Resection and Adjuvant Chemotherapy in Non-Small Lung Cancers

  • In-House Trials

    Breast Pilot Study

    The Impact of Exercise on Fatigue in Newly Diagnosed Breast Cancer Patients While Receiving Radiation Therapy

    Cancer Survivor Pilot Study

    Cancer Survivors’ Experience of Residential Walkability

    Breast Pilot Study

    Patient’s perspective on their decision for close follow-up versus biopsy after a mildly suspicious abnormal diagnostic mammogram