Nightingale provides rapid transport of the critically ill or injured, transporting patients from the scene of an accident, or from one medical facility to another. Nightingale operates as a community asset to EMS and multiple hospital systems, and is called into service when time is critical to the patient's survival and air transportation is the best method. She is often able to reach areas with limited access or assist communities where long transports would tie up limited EMS resources.
Nightingale's coverage area is a 125 nautical mile radius from its base at Sentara Norfolk General Hospital.
Scene flight requests comprise about 35% of Nightingale’s flights. They involve the treatment and transfer of patients directly from the scene of an incident or medical emergency. Scene operations are generally very quick, striving to reduce ground time to a minimum.